RELAPSED/REFRACTORY MULTIPLE MYELOMA-TRANSFORMED PLASMA-CELL LEUKEMIA SUCCESSFULLY TREATED WITH DARATUMUMAB FOLLOWED BY AUTOLOGOUS STEM CELL TRANSPLANTATION

Daratumumab is a humanized anti-CD38 IgG1 monoclonal antibody which could be used for multiple myeloma (MM).MM with plasma-cell leukemia (PCL) transformation is highly aggressive and is resistant to conventional therapy.Novel therapeutics are needed for PCL, and daratumumab may play role.We report a case of relapsed/refractory multiple myeloma (RRM

Abstract Background Within the manufacturing sector, assembly processes relying on mechanical fasteners such as nuts, washers, and bolts hold critical importance.Presently, these fasteners undergo manual inspection or are identified by human operators, a practice susceptible to errors that can adversely affect product efficiency and safety.Given co

Thermal storage tank is a standout amongst the most encouraging methods in solar thermal power stations operation.Accurate selection of appropriate Pedal Top storage system is a significant parameter to ensure the continuous working of thermal solar station during the absence of the sun.This work describes financial analysis of different locations

Abstract Background Germ lines Lateral File are the cell lineages that give rise to the sperm and eggs in animals.The germ lines first arise from primordial germ cells (PGCs) during embryogenesis: these form from either a presumed derived mode of preformed germ plasm (inheritance) or from an ancestral mechanism of inductive cell-cell signalling (in